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Valtrex is an antiviral medicine recommended for the remedy of shingles, cold sores, and simplex genitalis. It is also recommended for the decrease of HSV transmission from individuals with recurring viruses and CMV disease prevention after an organ transplant.

The generic version is valacyclovir or valaciclovir. Valacyclovir was marketed with the title  Valtrex and Zelitrex by GlaxoSmitheKline.  Valtrex acts by blocking the replication of viral DNA. It is a prodrug, not working actively in the body. Instead, it becomes acyclovir and this component targets the viruses. Acyclovir is also available as a topical medication but valacyclovir has a prolonged duration of operation than acyclovir.

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